The present invention relates to a surface exposed protein (protein E； pE), a virulencefactor, which can be detected in Haemophilus influenzae, having an amino acidsequence as described in SEQ ID NO 1, an immunogenic fragment of said surface exposedprotein, and a recombinant immunogenic protein (pE (A) ) or truncated variantsthereof based on said surface exposed protein. Nucleic acid sequences, vaccines,plasmids and phages, non human hosts, recombinant nucleic acid sequences, fusionproteins and fusion products are also described. A method of producing the saidprotein or truncated fragments thereof recombinantly is also disclosed.
