HANMI FINE CHEMICAL CO., LTD.; LTD.;HANMI FINE CHEMICAL CO.;한미정밀화학주식회사
发明人:
KIM, YUR IM,김유림,PARK, EUN RANG,박은랑,KWON, BO SUNG,권보성,CHO, YOUNG BUM,조영범,CHU, JUN HO,주준호,KIM, YUR IMKR,PARK, EUN RANGKR,KWON, BO SUNGKR,CHO, YOUNG BUMKR,CHU, JUN HOKR
申请号：
KR1020160023217
公开号：
KR1020170100842A
申请日:
2016.02.26
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to an improved method for producing a high purity poly(ethylene glycol) dialdehyde derivative. The production method of the present invention uses, as an intermediate, polyethylene glycol (PEG)-diacetal which is obtained via a reaction between dialkoxy-1-propanol and polyethylene glycol methanesulfonate. According to the present invention, it is possible to produce, in high yield, poly(ethylene glycol) dialdehyde derivatives suitable to be used as raw materials for drugs owing to high purity and activities of terminal ends.본 발명은 고순도의 폴리에틸렌글리콜 디알데히드 유도체를 제조하는 개선된 방법에 관한 것으로서, 상기 제조방법은 폴리에틸렌글리콜 메탄설포네이트를 디알콕시-1-프로판올과 반응시켜 제조된 PEG-디아세탈을 중간체로 사용함으로써, 순도 및 말단활성이 높아 의약품의 원료로 적합한 폴리에틸렌글리콜 디알데히드 유도체를 고수율로 제공할 수 있다.
