Stabilized polypeptides as regulators of RAB GTPase function

• 收藏
• 分享

专利权人:

Raymond E. Moellering

发明人:

Raymond E. Moellering,Gregory L. Verdine

申请号：

US14126642

公开号：

US09487562B2

申请日:

2012.06.15

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention provides inventive polypeptides comprising a C terminal RAB binding domain (RabBD) of RAB family interacting proteins (FIPs) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating RAB function comprising contacting an inventive stapled polypeptide with a RAB protein, and methods of treatment associated with modulation of RAB activity. The present invention also provides methods of making the inventive stapled polypeptides by ring closing metathesis of unstapled polypeptide precursors.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/