Dialysis machine (10) with - at least one input means (20), which is configured to enable the entry of parameters for at least a concentration of at least one substance dissolved in the vascular blood circulation of the patient； - a calculation unit (32), which is configured to, by providing a model at least including the parameters previously introduced or an iterative calculation based on the parameters for at least a concentration of this substance dissolved in the vascular blood circulation of the In the form of the initial concentration of the dissolved substance and the volume of distribution of the patient, as well as the dialysis or clearance of this substance, calculate and / or evaluate the development of the variation in concentration to be expected through treatment of dialysis and / or final value to be expected from the concentration of this substance in the vascular blood circulation of the patient； and - a control and / or regulation unit (34), which is configured to, depending on this evaluation by means of output (20), emit at least one signal and / or an indication and / or influence the dialysis treatment ； - the control and / or regulation unit (34) being configured to influence the settings on the machine side for dialysis treatment, in terms of treatment duration, dialysate composition, flow rate adjustment in the blood circulation and / or dialysate circuit and / or adjustment of the type of dialysis treatment, preferably influencing the composition of the dialysate by controlling a dosage unit (15) for concentrating dialysate components and / or flow rates by controlling pumps (13) of the blood circulation and / or dialysate circuit.Máquina para diálisis (10) con - al menos un medio de entrada (20), que está configurado para posibilitar la entrada de parámetros para al menos una concentración al menos de una sustancia disuelta en la circulación sanguínea vascular del paciente； - una unidad de cálculo (32), que está configurada para, al facil
