Methods, apparatus, and other embodiments associated with predicting Crohns Disease (CD) patient response to immunosuppressive (IS) therapy using radiomic features extracted from diagnostic magnetic resonance enterography (MRE). One example apparatus includes an image acquisition circuit that acquires an MRE image of a region of tissue demonstrating CD pathology, a segmentation circuit that segments a region of interest (ROI) from the diagnostic radiological image, a classification circuit that extracts a set of discriminative features from the ROI and that distinguishes the ROI as a responder or non-responder to IS therapy, and a CD prediction circuit that generates a radiomic enterographic (RET) score based on the diagnostic radiological image or the set of discriminative features. A prognosis or treatment plan may be provided based on the RET score.
