p-Ethoxy nucleic acids for liposomal formulation

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专利权人:

Bio-Path Holdings; Inc.

发明人:

Peter Nielsen

申请号：

US15294223

公开号：

US09744187B2

申请日:

2016.10.14

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

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http://www.ckcest.cn/home/