Systems and methods for biopsy guidance are provided. One system includes a gantry and a breast immobilization plate mounted to the gantry, wherein the breast immobilization plate is configured to be coupled with a biopsy unit. The biopsy unit includes at least one nuclear medicine imaging detector in an angled orientation with respect to the breast immobilization plate. The breast imaging system also includes a nuclear medicine imaging detector mounted to the gantry parallel to the breast immobilization plate, wherein the nuclear medicine imaging detector mounted to the gantry and the breast immobilizing plate are configured to immobilize a breast therebetween.
