The present invention relates to the nano particles of the albumin of load 5FU and/or 5FU precursors. Moreover, it relates to the precursor of the pharmaceutical composition comprising nano particle or 5FU delivery systems and/or 5FU. Purposes the invention further relates to the precursor of method and nano particle, pharmaceutical composition or 5FU delivery systems and/or 5FU for producing the nano particle as medicament, especially for being used in the treatment of tumour.