#$%^&*AU2012201226B220140814.pdf#####ABSTRACT The present invention relates to novel anesthetic compositions containing a nonpolymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided. Preferably the composition contains bupivacaine and a sugar ester such as saib. 1632541_.doc-~First supplemental algsc(Avg) c 25 20. .215. 0 10 2 0 3 0 4 0 5 0 6 0 70 80 90 Time (Hours) -.- SABER Buplv + Saline --- SABER Bupiv + Buplv -A Bupiv + Bupiv FIGURE 6 6/6
