The present invention relates to novel technology suitable for reducing errors introduced into the process of medication administration. In particular, the present invention provides an instrument for on demand printing of patient database information directly to medication packaging, e.g., multi-compartment packaging, through a patient database interfacing control unit (DICU), which is capable of generating a dose label for a multi-compartment package, wherein each compartment label of the complete package label is independently compliant to state guidance documents incorporating the requirements of the five rights for split package administration. Accordingly, the present invention provides multi-compartment dosage cards engineered for safer split package administration, and systems to produce such cards.