CHILDREN'S NATIONAL MEDICAL CENTER;UNIVERSITY OF MARYLAND, COLLEGE PARK
发明人:
Alexander I. SON,Kazue HASHIMOTO-TORII,Masaaki TORII,Paul D. MORTON,Seiji ISHII,Justin OPFERMANN,Judy LIU,John FISHER,Marco SANTORO,Peter C.W. KIM
申请号：
US16645221
公开号：
US20200289250A1
申请日:
2018.09.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interior void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.
