Janssens, Frans Eduard,Poncelet, Alain Philippe,Schoentjes, Bruno,Coupa, Sophie,Simonnet, Yvan Rene Ferdinand
申请号：
AU2006221984
公开号：
AU2006221984C1
申请日:
2006.03.03
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
This invention concerns substituted diaza-spiro-[4.4]-nonane derivativeshaving neurokinin antagonistic activity, in particular NK1 antagonist ic activity,their preparation, compositions comprising them and their use as a medicine,in particular for the treatment and/or prophylaxis of schizophrenia, emesis,anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances,pre-eclampsia, nocicept ion, pain, in particular visceral and neuropathicpain, pancreatitis, neurogenic inflammation, asthma, chronic obstructivepulmonary disease (COPD) and micturition disorders such as urinary incont inence.The compounds according to the invention can be represented by general Formula(I) and comprises also the pharmaceutically acceptable acid or base additionsalts thereof, the stereochemically isomeric forms thereof, the N-oxide formthereof and prodrugs thereof, wherein all substituents are defined as in Claim1.
