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Preparation method of MLN4924 as an E1 activating inhibitor
专利权人:
Lak Shin Jeong
发明人:
Lak Shin Jeong,Hyuk Woo Lee
申请号:
US13425212
公开号:
US08716304B2
申请日:
2012.03.20
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to a method for preparation of MLN4924 as an E1 activating inhibitor, and more specifically, to a method for efficient and stereoselective preparation of MLN4924 by means of key steps involving stereoselective reduction of cyclopentenone with isopropylidene, regioselective cleavage of isopropylidene moiety, and synthesis of cyclic sulfate.
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中国工程科技知识中心
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