A pesticide composition for controlling Fusarium head blight, which contains 1 to 150 parts by weight of jinggangmycin and 1 to 30 parts by weight of tebuconazole. The pesticide composition of the present invention has an obvious synergistic effect when used for controlling Fusarium head blight, can remarkably enhance the effect of controlling Fusarium head blight, and increase the ability of the human being in controlling Fusarium head blight of grain crops.