LI, Liansheng,CAMPBELL, Simon Fraser,REN, Pingda,LIU, Yi,CHAN, Katrina,WILSON, Troy Edward
申请号：
PE0021942016
公开号：
PE00032017A1
申请日:
2010.08.17
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a compound of formula I, where W1 is Cr3, CR4 is W3 W2, W4 is is n n or C W5 is n or CR7 W6 is n or CR8 r1 is Hydrogen, alkyl or heterocicloalquilo C3 C1 - C10 C18 amino R2 is R3 is Hydrogen, heterocicloalquilo C3 - C18, among others R4 is Hydrogen, amino or C1 - C10 alkyl and R R7 8 are independently Hydrogen or alkyl of C1 - C10.Preferred compounds are: [6 - (2 - amino - 1.3 - benzoxazole - 5 - il) imidazo [1,2-a] pyridin-3-yl] (metilpiperazin - 4 - 1 - il) methanone [6 - (2 - amino - 1.3 - benzoxazole - 5 - il) imidazo [1,2-a] pyridin-3-yl] - 4 - (IL) methanone among others. It also relates to a Pharmaceutical composition.These compounds modulate the activity of PI3 kinase, being useful in the treatment of cancer, Leukemia, cancer of the Thymus, among others.Se refiere a un compuesto de formula I, donde: W1 es CR3 W2 es CR4 W3 es N W4 es N o C w5 es N o CR7 W6 es N o CR8 R1 es hidrogeno, alquilo C1-C10 o heterocicloalquilo C3-C18 R2 es amino R3 es hidrogeno, heterocicloalquilo C3-C18, entre otros R4 es hidrogeno, amino o alquilo C1-C10 R7 y R8 son independientemente hidrogeno o alquilo C1-C10. Son compuestos preferidos: [6-(2-amino-1,3-benzoxazol-5-il)imidazo[1,2-a]piridin-3-il](4-metilpiperazin-1-il)metanona [6-(2-amino-1,3-benzoxazol-5-il)imidazo[1,2-a]piridin-3-il](morfolin-4-il)metanona entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos modulan la actividad de la PI3 quinasa, siendo utiles en el tratamiento de cancer, leucemia, cancer de timo, entre otros.
