SHI, LEI,BUNNELLE, WILLIAM H.,LI, TAO,SCANIO, MARC J.,SCHRIMPF, MICHAEL R.,LEE, CHIH-HUNG
申请号：
ES10801031
公开号：
ES2512241T3
申请日:
2010.12.14
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) or (II), comprising: or a pharmaceutically acceptable salt thereof, wherein a is a single or double bond； k is 1.2, or 3； h is 1.2, or 3； m is 0, 1, or 2； n is 1 or 2, where the sum of k, m, and n is 3, 4, or 5； X is O, S, S (O), S (O) 2, or a link； L is - [C (Ra) (Rb)] p-, - [C (Ra) (Rb)] q1 - [(CRc)>； = (CRd)] - [C (Ra) (Rb)] q2-, - [C (Ra) (Rb)] rr [C>； = CHC (RaHRb)] r2-, - [C (Ra) (Rb)] s-cyclopropylene- [C (Ra) (Rb)] t-, or a link； or X and L taken together are a link； Q is a substituted or unsubstituted monocyclic aryl, substituted or unsubstituted bicyclic aryl, substituted or unsubstituted monocyclic heteroaryl, or substituted or unsubstituted bicyclic heteroaryl； R 2 is hydrogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, or C 2 -C 4 alkynyl, where C 1 -C 4 alkyl, and the saturated carbon atoms of C 2 -C 4 alkenyl and C 2 -C 4 alkynyl, may be unsubstituted or substituted by hydroxyl, C1-C8 alkyl, C1-C8 haloalkyl, carboxy, or alkoxycarbonyl； R3 is hydrogen, halogen, C1-C5 haloalkyl, C1-C5 alkoxy, C1-C5 haloalkoxy, or cyano； Ra, Rb, Rc, and Rd are, whenever hydrogen, halogen, C1-C8 alkyl, C1-C8 haloalkyl, carboxy, or alkoxycarbonyl appears independently； p is 1,2, 3, 4, or 5； q1 and q2 are independently 0, 1, 2, or 3, with the proviso that the sum of q1 and q2 is 0, 1, 2, or 3； r1 and r2 are independently 0, 1, 2, or 3, with the proviso that the sum of r1 and r2 is 0, 1, 2, or 3； s is 0, 1 or 2； and t is 0 or 1； where Q, when substituted, is independently substituted with 1,2, 3, 4, or 5 substituents, where the substituent is halogen, cyano, C1-C5 haloalkyl, C1-C5 alkyl, C2-C5 alkenyl, alkynyl C2-C5-, hydroxy, C1-C5 alkoxy, haloalkyl -O-C1-C5-, alkyl -S-C1-C5-, haloalkyl -S-C1-C5-, alkyl-SO2-C1-C5, haloalkyl-SO2-C1-C5, cyanoalkyl C1-C5-, or -NO2.Un compuesto de fórmula (I) o (II), que comprende: o una de sus sales farmacéuticamente aceptables, en la que a es un enlace simple o doble； k es 1,2, o 3； h es 1,2, o 3； m es 0, 1, o 2； n es 1 o
