PYRROLOCARBOXAMIDES EN TANT QUE MODULATEURS DE L'ACTIVITE D'UN RECEPTEUR ORPHELIN GAMMA (RORY, NR1F3) APPARENTE AU RECEPTEUR NUCLEAIRE ORPHELIN RAR ET DESTINES AU TRAITEMENT DE MALADIES INFLAMMATOIRES CHRONIQUES ET AUTO-IMMUNES
STEENECK, CHRISTOPH,KINZEL, OLAF,GEGE, CHRISTIAN,KLEYMANN, GERALD,HOFFMANN, THOMAS
申请号：
CA2856946
公开号：
CA2856946C
申请日:
2012.12.03
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.
