PROBLEM TO BE SOLVED: To provide micellar nano-carriers for in vivo delivery of drugs and other cargos.SOLUTION: Disclosed is a conjugate comprising: a first peptide having from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure； a first polymer covalently linked to an amino acid residue of the peptide, other than the N-terminal and C-terminal amino acid residues； at least one second polymer covalently linked to the C-terminal amino acid residue of the peptide； and a hydrophobic moiety covalently linked to the N-terminal of the peptide, wherein the hydrophobic moiety comprises a third polymer or a lipid moiety.SELECTED DRAWING: Figure 1【課題】ｉｎ ｖｉｖｏでの薬物及び他の積荷の送達のためのミセルナノキャリアの提供。【解決手段】約１０～約１００個のアミノ酸を有する第一のペプチド、ここで、前記ペプチドが、らせん構造をとり；前記ペプチドのＮ末端及びＣ末端アミノ酸残基以外のアミノ酸残基に共有結合した第一のポリマー；前記ペプチドのＣ－末端アミノ酸残基に共有結合した少なくとも１つの第二のポリマー；並びに前記ペプチドのＮ－末端に共有結合した疎水性部分、ここで、前記疎水性部分が、第三のポリマーまたは脂質部分を含む、複合体。【選択図】図１
