There is disclosed device and method provide efficient, comfortable and accurate positioning of a treatment device relative to a specific cranial anatomical location of a subject. In an embodiment, the method comprises: placing a fixed-position locating device on the cranium of the subject； placing an adjustable positioning cap on the cranium of the subject； loading a subject-specific calibration for treatment of a specified cranial anatomical location； determining a three-dimensional position of the fixed-position locator device relative to the adjustable positioning cap； and calibrating the location of the positioning cap by adjusting the positioning cap until it is aligned with the specified cranial anatomical location.
