Thomas Nixey;Stephen A. Hitchcock;Joseph L. Kim;Nick A. Paras;Adrian Leonard Smith;Gang Liu;Jian J. Chen;Daniel Martin Retz;Frenel F. De Morin;Jiawang Zhu;Jeffrey Petkus;Elizabeth M. Doherty;Qi Huang
发明人:
Frenel F. De Morin,Jian J. Chen,Elizabeth M. Doherty,Stephen A. Hitchcock,Qi Huang,Joseph L. Kim,Gang Liu,Thomas Nixey,Nick A. Paras,Jeffrey Petkus,Daniel Martin Retz,Adrian Leonard Smith,Jiawang Zhu
申请号：
US13163666
公开号：
US08440674B2
申请日:
2011.06.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula Iwherein R1 isand A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
