ISOLATED HUMAN MONOCLONAL ANTIBODY OR ANTIGEN CONNECTION PORTION OF THE SAME, ISOLATED POLYPEPTIDE, COMPOSITION, ISOLATED NUCLEIC ACID, EXPRESSION VECTOR, HOST VECTOR, Hepatitis C, HCV VT, HCV VT HEPATITIS C (HCV) AND TO IDENTIFY ANTIBODY OR FRAGMENT OF THE SAME, ANTIBODY OR FRAGMENT OF THE SAME, AND HEPATITE C (HCV) RECOMBINANT E2 PROTEIN
TERESA BROERING,SUSAN SLOAN,GREGORY J. BABCOCK,DONNA AMBROSINO,JR. WILLIAM D. THOMAS
申请号：
BRPI0807929
公开号：
BRPI0807929A2
申请日:
2008.02.13
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
