JAESCHKE, GEORG,LINDEMANN, LOTHAR,STADLER, HEINZ,VIEIRA, ERIC
申请号：
PH12015500261
公开号：
PH12015500261A1
申请日:
2015.02.06
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula I wherein R1 is hydrogen or halogen； R2 is C1-3-alkyl or -(CH2)m-O-CH3； n is 2 or 3； m is 1 or 2； or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) with improved properties for the treatment of schizophrenia, cognitive diseases, fragile X syndrome or autism.
