ДЖОЙС Джозеф Дж. (US),ВУ Чэнвэй (US),ОТТИНДЖЕР Элизабет А. (US),ГАРСКИ Виктор (US)
申请号：
RU2014141896
公开号：
RU2014141896A
申请日:
2013.03.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A peptide mimetic of gp41, including the core frame associated with the three N-peptides each having an amino acid sequence comprising N36 (SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL SEQ ID NO: 1) or its modified version, where the three N-peptide interact with each other to form a trimeric coiled helix conformation simulating predshpilki HIV gp41, with the proviso that the active peptide mimetic is not gp41 (CCIZN36) .2. Peptide mimetic according to claim gp41. 1, wherein each of the three peptides is covalently bonded to the frame in different points of the core prisoedineniya.3. Peptide mimetic according to claim gp41. 1, wherein the core skeleton comprises hydrochloride, tris (2-carboxyethyl) phosphine trissuktsinimidilaminotriatsetat, tris (2-maleimidoetil) amine, KTA-bromide or cholic acid, or consists of nih.4. Peptide mimetic according to claim gp41. 3, wherein the core is a carcass KTA-bromide or cholic kislotu.5. Peptide mimetic according to claim gp41. 1, wherein the core skeleton represents a linear polypeptide chain comprising three functional residue, ensuring adherence three N-peptidov.6. . The peptide mimetic gp41 according to claim 5, wherein the frame core comprises: a) CHCO-Ava-Lys-Ava-Lys-Ava-Lys-Ava-NH (SEQ ID NO: 41) b) SHCO-Arg-Lys-Arg -Lys-Arg-Lys-Arg-NH (SEQ ID NO: 42) c) CHCO-Glu-Lys-Glu-Lys-Glu-Lys-Glu-NH (SEQ ID NO: 43) d) CHCO-Cys -Arg-Lys-Arg-Lys-Arg-Lys-Arg-NH (SEQ ID NO: 44) Ilie) CHCO-Cys-Glu-Lys-Glu-Lys-Glu-Lys-Glu-NH (SEQ ID NO: 45 .7). Peptide mimetic according to claim gp41. 2, wherein the frame core is a carbocyclic skeleton comprising cyclohexane, cycloheptane or tsiklooktan.8. Peptide mimetic according to claim gp41. 2, wherein the frame core is a heterocyclic skeleton vklyuchayuschiypirrolidin, oxolane, thiolane, priperidin, oxane, Tian, azepane, oksepan, tiepan, piperazine, morpholine or tiomorfolin.9. . Gp41 peptide mimetic of claim 1, wherein the one or more peptides include N-N51 (QARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL
