Use of kinase inhibitors for the treatment of certain resistant tumors

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专利权人:

ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ

发明人:

フアンチエツリ，ダニエレ,イザツキ，アントネツラ,モドウーニヨ，ミケーレ,モル，ユルゲン,ルスコーニ，ルイーザ,ソンチーニ，キアラ,ルピ，ロジータ,フアンチエツリ,ダニエレ,イザツキ,アントネツラ,モドウーニヨ,ミケーレ,モル,ユルゲン,ルスコーニ,ルイーザ,ソンチーニ,キアラ,ルピ,ロジータ

申请号：

JP2009502095

公开号：

JP5274444B2

申请日:

2007.03.29

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/