A portable therapy device for treating mental health disorders, syndromes or diseases includes (a) a wearable headband comprising at least one transducer element, comprising a piezoelectric crystal, a liquid coupling medium, and an elastomeric cap； and (b) a controller for causing the transducer to produce low-intensity pulsed ultrasound (LIPUS). A method of treating a mental health disorder, syndrome or disease in a mammal such as a human includes the step of applying LIPUS directly to the cranium of the mammal.
