Refers to a compound oxacina Derivative of formula (i) where X is o or s r1 is H, halogen, alkyl, cyano, C1 - 8, among others R2 is an aryl, heteroaryl, among others R3 is H, halogen, alkyl, cyano, haloalquilo C1 C1 - 8 - 8 among others R4 is H, halogen, alkoxyl 8 Ciano, C1 -, Halo - alkoxyl C 1 - 8, among others R5 is H, cyano, alquenilo 8 alquinilo C2, C2 8Among others, R4 and R5 are together - C (H) = C (H) - C (H) = C (H) or alquileno C1 - 8, among others R6 is H, alkyl C1 - 8 8 -, Halo - C1 alkyl, alkoxyl alkyl (C1 - C1 - (8) 8), among others. He is cr7r8 - among others - cr11r12 E2 is, among others, R7 and R8 are independently h, halogeno, cyano, among others, together. N oxo or - CH2 - CH2 -, R11 and R12 are independently h, halogeno, cyano, among others.Together or are oxo - CH2 - CH2 -.Preferred compounds are: [3 - (3 - amino - 5 - methyl - 3.6 - dihydro - 2H - [1,4] - oxazin - 3 - il) phenyl] - amide Furan carboxylic acid - 2 - 5 - methyl - [3 - (3 - amino - 5 - methyl - 3.6 - dihydro - oxazin - 2H - [1,4] - 3 - yl) - phenyl] pyridin-3 - amide carboxylic acid - 2 -, 3 - Chloro - [3 - (3 - amino - 5 - methyl - difluoro - 3.6 - dihydro - 2H - [1,4] - oxazin - 3 - IL) phenyl] - amide acid, trifluoro - 5 - methyl - 2 - pyridin - carboxylic acid, among others.It also relates to a Pharmaceutical Composition and a preparation method. This Compound is an inhibitor of the Enzyme beta secretase (BACE) is useful in the treatment of Alzheimers diseaseSE REFIERE A UN COMPUESTO DERIVADO DE OXACINA DE FORMULA (I) DONDE: X ES O O S R1 ES H, CIANO, HALOGENO, ALQUILO C1-8, ENTRE OTROS R2 ES ARILO, HETEROARILO, ENTRE OTROS R3 ES H, CIANO, HALOGENO, ALQUILO C1-8, HALOALQUILO C1-8, ENTRE OTROS R4 ES H, HALOGENO, CIANO, ALCOXILO C1-8, HALO-ALCOXILO C1-8, ENTRE OTROS R5 ES H, CIANO, ALQUENILO C2-8, ALQUINILO C2-8, ENTRE OTROS R4 Y R5 JUNTOS SON -C(H)=C(H)-C(H)=C(H) O ALQUILENO C1-8, ENTRE OTROS R6 ES H, ALQUILO C1-8, HALO-ALQUILO C1-8, ALCOXILO(C1-8)-ALQUILO(C1-8), ENTRE OTROS E
