The disclosure relatesto protease-binding agent specific fora protease. The agent may be an antibodycapable of specifically bindingand inhibiting a protease, such as aP1-Arg-specific protease. The disclosurealso provides methods of producing,and compositions comprisingthe subject agent. Methods and kitsrelated to the protease-binding agentfind use in protection against, detection,diagnosing, treating cancer andinfections due to pathogens containingactive proteases.
