An agricultural multi-fluid spray system (20) is disclosed. The system (20) comprising: a plurality of working fluid sources (24, 26); a plurality of lines (34, 36) carrying a plurality of working fluids from the plurality of working fluid sources (24, 26); and a first spray nozzle (30, 130, 230) having a plurality of inlets (48, 54, 148, 154) coupled to the plurality of lines (34, 36) and having a plurality of outlets (52, 58, 60, 104, 114) selectively coupled to the plurality of inlets (48, 54, 148, 154), the first spray nozzle (30, 130, 230) having at least one control valve (70, 78, 53, 170, 178) operatively positioned between the plurality of inlets (48, 54, 148, 154) and the plurality of outlets (52, 58, 60, 104, 114), the first spray nozzle (30, 130, 230) being configured to segregate the plurality of working fluids into a plurality of fluid paths (50, 56) within the first spray nozzle (30, 130, 230) upstream of the at least one control valve (70, 78, 53, 170, 178), the at least one control valve (70, 78, 53, 170, 178) being configured and controlled to selectively route the plurality of fluid paths (50, 56) to one or more of the plurality of outlets (52, 58, 60, 104, 114).