A system includes one or more optical sensors for the measuring and monitoring of physiological information of a motorized system operator. The system is configured to determine an incapacitation state of the motorized system operator based upon the measured physiological information. When the measured physiological information indicates an incapacitation state (intoxication level, stress level, and so forth), the system is configured to provide a response thereto including, but not limited to: lock out operation of the motorized system, provide a warning on a display, transmit a message from the motorized system, assume automatic control of the motorized system, and so forth. The system includes a plurality of light sources (e.g., light-emitting diodes (LEDs)), one or more photodetectors, and control circuitry coupled to the plurality of light sources and/or photodetectors to non-invasively measure physiological information (e.g., blood alcohol concentration, stress levels, and so forth).