The Board of Regents of The University of Texas Sy
发明人:
OLSON, Eric,VAN ROOIJ, Eva
申请号：
HK10110330.6
公开号：
HK1143948B
申请日:
2010.11.04
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
