The present invention relates to eutectiferous combination of oral medication comprising C16H25NO2 (tramadol) and celecoxib (celecoxib), preparation method and its as drug, more specifically, with the purposes of what treatment pain.本發明涉及包含曲馬多(tramadol)和塞來昔布(celecoxib)的共晶體的口服藥物組合物、其製備方法及其作爲藥物,更具體而言,用於治療疼痛的用途。