The present disclosure provides antibodies and antigen binding fragments capable of binding to PAR2. In some embodiments, anti-PAR2 antibodies or antigen binding fragments thereof bind to PAR2 in a pH dependent manner. The disclosure further provides methods for preparing and using the antibodies and antigen-binding fragments.The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.La presente divulgación proporciona anticuerpos y fragmentos de unión a antígeno capaces de unirse a PAR2. En algunas realizaciones, los anticuerpos anti-PAR2 o fragmentos de unión a antígeno de los mismos se unen a PAR2 de una manera dependiente del pH. La divulgación proporciona además métodos para preparar y usar los anticuerpos y fragmentos de unión a antígeno.The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.