SIADAK, ANTHONY W.,BILSBOROUGH, JANINE,RENE, SHIRLEY
申请号：
DK13154481
公开号：
DK2594586T3
申请日:
2007.09.04
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
There is provided an isolated monoclonal antibody or antigen-binding fragment thereof that competes with the monoclonal antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815 for binding to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:2； wherein the monoclonal antibody has a human IgG4 heavy chain immunoglobulin constant domain or wherein the antigen-binding fragment further comprises a human IgG4 heavy chain immunoglobulin constant domain； and wherein the monoclonal antibody or antigen-binding fragment inhibits signal transduction induced by the polypeptide through its heterodimeric receptor.
