Refers to a Pharmaceutical composition comprising: (a) The Compound (S) - N - (2 - (3,4 - difluoro - yodofenilamino 2-fluoro-4 - (6) - 4-methoxyphenyl) - 1 - (2,3-dihydroxypropyl) ciclopropan sulfonamide - 1 and (b) one of the compounds (i) 3 - (6,7-bis (2-methoxyethoxy) quinazolin-4 ilamino) benzonitrile, (ii) n - (3-chloro-4 fluo Rofenil) - 7 - methoxy - 3 - (3 - morfolinopropoxi) quinazolin-4 - Amine (iii) 4 - amino - 1 - [3Difluoro - 4 - hydroxy - 3 - 5 - (hydroxymethyl) - yl] tetrahydrofuran-2-ylmethyl 2 - 1H pyrimidine 2 - ona, IV) n - hydroxy phenyl - n - octandiamida, V) - 4 - methyl - 5 - oxo 2,3,4,6,8 pentazabiciclo [4.3.0] 2,7,9 triennium 2008-2010 nona - - - 9 - carboxamide, among Others. Said composition is a synergistic combination is useful in the treatment of non small cell lung cancer, Breast Cancer, Thyroid cancer, melanoma, Pancreatic CancerSE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) EL COMPUESTO (S)-N-(3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)-6-METOXIFENIL)-1-(2,3-DIHIDROXIPROPIL)CICLOPROPAN-1-SULFONAMIDA Y B) UNO DE LOS COMPUESTOS i) 3-(6,7-BIS(2-METOXIETOXI)QUINAZOLIN-4-ILAMINO)BENZONITRILO, ii) N-(3-CLORO-4-FLUOROFENIL)-7-METOXI-6-(3-MORFOLINOPROPOXI)QUINAZOLIN-4-AMINA, iii) 4-AMINO-1-[3,3-DIFLUORO-4-HIDROXI-5-(HIDROXIMETIL)TETRAHIDROFURAN-2-IL]-1H-PIRIMIDIN-2-ONA, iv) N-HIDROXI-N-FENIL-OCTANDIAMIDA, v) 4-METIL-5-OXO-2,3,4,6,8-PENTAZABICICLO[4.3.0]NONA-2,7,9-TRIEN-9-CARBOXAMIDA, ENTRE OTROS. DICHA COMPOSICION ES UNA COMBINACION SINERGICA SIENDO UTIL EN EL TRATAMIENTO DE CANCER DE PULMON DE CELULA NO PEQUENA, CANCER DE MAMA, CANCER DE TIROIDES, MELANOMA, CANCER DE PANCREAS
