The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs. The present invention also provides a method of treating or preventing a condition of the airway or lung involving fibrosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1 or an inhibitor of ALK5, thereby treating or preventing a condition of the airway or lung involving fibrosis in a subject.La présente invention concerne des compositions, méthodes et kits pour le traitement de maladies respiratoires. En particulier, les compositions, méthodes et kits sont en particulier utilisables, entre autres, dans le traitement ou la prévention des exacerbations de l'asthme et de la broncho-pneumopathie chronique obstructive. La présente invention concerne une méthode de traitement ou de prévention d'une maladie respiratoire chez le patient en ayant besoin, la méthode comprenant l'administration au patient d'une quantité thérapeutiquement efficace d'un inhibiteur de la caséine kinase 1, ce qui permet le traitemen
