AGONISTES DU RECEPTEUR DU TYPE GUANYLATE CYCLASE POUR STIMULER LE TRANSPORT D'EAU DANS LE TRACTUS GASTRO-INTESTINAL POUR TRAITER L'INFLAMMATION DES TISSUS
SHAILUBHAI, KUNWAR,JACOB, GARY S.,NIKIFOROVICH, GREGORY
申请号：
CA2795396
公开号：
CA2795396C
申请日:
2002.03.28
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular production of cGMP. The at least one peptide agonist of a guanylate cyclase receptor may be administered either alone or in combination with an inhibitor of cGMP--dependent phosphodiesterase. The inhibitor may be a small molecule, peptide, protein or other compound that inhibits the degradation of cGMP. Without requiring a particular mechanism of action, this treatment may restore a healthy balance between proliferation and apoptosis in the subject's population of epithelial cells, and also suppress carcinogenesis. Thus, the method may be used to treat, <；i>；inter alia<；i/>；, inflammation, including gastrointestinal inflammatory disorders, general organ inflammation and asthma, and carcinogenesis of the lung, gastrointestinal tract, bladder, testis, prostate and pancreas, or polyps.
