The invention relates to nitrooxy derivatives of fluocinolone acetonide,triamcinolone acetonide, betamethasoneand beclomethasone, methods for their preparation, pharmaceutical compositionscontaining these compounds, and methods ofusing these compounds and compositions for treating diabetic macular edema,diabetic retinopathy, macular degeneration, age-re-latedmacular degeneration and other diseases of retina and macula lutea.