Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents. Other embodiments relate to pharmaceutical compositions containing boronic acid derivatives and additional excipient such as meglumine.本文揭示抗微生物化合物、組合物、醫藥組合物、其用途及製備。一些實施例係關於硼酸衍生物及其作為治療劑之用途。其他實施例係關於含有硼酸衍生物及其他賦形劑(例如葡甲胺)之醫藥組合物。