A floating transducer drive configured to isolate relatively low voltage system electronics from a relatively high voltage transmit circuit in an ultrasound imaging system. A receive circuit is electrically connected to an isolated local ground. An isolation circuit is electrically connected between the receive circuit and a relatively low-voltage processing circuit. The isolation circuit is configured such that during a transmit event during which the relatively high voltage transmit circuit sends a relatively high voltage signal to a transducer, the isolated local ground is electrically connected to the transmit circuit, but when the transmit event is not occurring, the isolated local ground is electrically connected to a system ground.