ALISHA B. ARRIGO,DONALD T. CORSON,CORALEE G. MANNILA
申请号：
ARP130100655
公开号：
AR090209A1
申请日:
2013.02.28
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The present provides a hydrogen chloride Salt of 1 - (3 - tert - butyl - 1 - P - tolyl - 1H pyrazole - 5 - yl) - 3 - (5-fluoro-2 - (1 - (2-hydroxyethyl) - 1H indazol - 5 - iloxi) benzyl) urea hydrochloride Crystalline forms, 1 - (3 - tert - Butyl - 1 - P - tolyl - 1H pyrazole - 5 - yl) - 3 - (5-fluoro-2 - (1 - (2-hydroxyethyl) - 1H indazol - 5 - iloxi) benzyl) urea processes for the preparation of these Crystalline forms,Pharmaceutical compositions containing a Crystalline form of the form B hydrochloride (1 - 3 - tert - butyl - 1 - P - tolyl - 1H pyrazole - 5 - yl) - 3 - (5-fluoro-2 - (1 - (2-hydroxyethyl) - 1H indazol - 5 - iloxi) benzyl) urea, processes for the preparation of such compositionsPharmaceutical compositions are prepared by these methods and the use of such compositions in the treatment of various diseases and disorders. Claim 1: a Crystalline polymorphic Form b hydrochloride (1 - 3 - tert - butyl - 1 - P - tolyl - 1H pyrazole - 5 - yl) - 3 - (5-fluoro-2 - (1 - (2-hydroxyethyl) - 1H indazol - 5 - iloxi) benzyl urea).Claim: 79 polymorphic according to claim 1, is characterized by diffraction Peaks of XRPD (2Q + 0.3 degrees to about 10.0, 12.3, 13.0, 15.9 17.6 16.9 18.5, 19.8, 20.4, 20.8, 21.5 21.9 22.4, 23.4 23.9 25.2 25.9 24.6,,,, 27.0 and 27.3.Claim: a 109 polymorphic Crystalline form a of hydrochloride of 1 - (3 - tert - butyl - 1 - P - tolyl - 1H pyrazole - 5 - yl) - 3 - (5-fluoro-2 - (1 - (2-hydroxyethyl) - 1H indazol - 5 - iloxi) benzyl urea).Crystalline Polymorph of 112 Claims: claims 109 is characterized by having at least ten diffraction Peaks of specific XRPD (2Q degrees (0.3) approximately 6.9 7.8, 13.9, 15.6, 16.7, 17.1, 19.2, 22.4, 22.8 and 26.6.En la presente se proporciona una sal de cloruro de hidrógeno de 1-(3-terc-butil-1-p-tolil-1H-pirazol-5-il)-3-(5-fluoro-2-(1-(2-hidroxietil)-1H-indazol-5-iloxi)bencil)urea, formas cristalinas de clorhidrato de 1-(3-terc-butil-1-p-tolil-1H-pirazol-5-il)-3-(5-fluoro-2-(1-(2-hidroxietil)-1H-indazol-5-
