A pump having a disposable fluid contacting portion which defines a fluid inletand outlet and a fluid path there between is presented. The pump includes a driveportion configured to engage the disposable portion to cause fluid to be movedfrom the fluid inlet to the fluid outlet. The disposable portion is configuredto be selectively coupled to the drive portion. The disposable portion includesa driven membrane which forms a portion of the fluid path, and the drive portionincludes a drive membrane. The two membranes are vacuum coupled to each other,whereby movement of the drive membrane causes the driven membrane to move, causingfluid to be pumped through the disposable portion. The pump has particular utilityin the medical field for moving fluid from a source to a patient. The pump may includefeatures such as an air-trap, bubble detection, fluid flow controls, and pressuredetection.