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Morpholino pyrimidine derivatives used in diseases related to mTOR kinase and / or PI3K
专利权人:
ASTRAZENECA AB;ASTRAZENECA AB
发明人:
PIKE, KURT GORDON
申请号:
ES08776183
公开号:
ES2385692T3
申请日:
2008.07.08
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of formula (I) ** Formula ** formula (I) or a pharmaceutically acceptable salt thereof; where it is 0, 1, 2, 3 or 4; 1Y and Y2 are independently N or CR8 as long as one of 1Y and Y2 is N and the other is CR8; X is a linking group that is selected from -CR4>; = CR5 -, -CR4>; = CR5CR6R7-, -CR6R7CR5>; = CR4-, -C≡C-, -C≡CCR6R7-, -CR6R7C≡C-, -NR4CR6R7-, -OCR6R7-, -SCR6R7-, -S (O ) CR6R7-, -S (O) 2CR6R7-, -C (O) NR4CR6R7-, -NR4C (O) CR6R7-, -NR4C (O) NR5CR6R7-, -NR4S (O) 2CR6R7-, -S (O) 2NR4CR6R7 -, -C (O) NR4-, -NR4C (O) -, -NR4C (O) NR5-, -S (O) 2NR4- and -NR4S (O) 2-; R1 is a group selected from hydrogen C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, carbocyclyl, C 1-6 carbocyclyl, heterocyclyl and C 1-6 heterocyclyl, and said group is optionally substituted by one or more substituent groups that are selected from halo, cyano, nitro, R 9, -OR9 , -SR9, -SOR9, -SO2R9, -COR9, -CO2R9, -CONR9R10, -NR9R10, -NR9COR10, -NR9CO2R10, -NR9CONR10R15, -NR9COCONR10R15 and -NR9SO2R10; N are always selected from A1 or A2 where A1 is always selected between A1 and A2 that at least one of A1 or A2 is CH; every R3, when pres entity, independently selected from halo, cyano, nitro, -R13, -OR13, -SR13, -SOR13, -SO2R13, -COR13, -CO2R13, -CONR13R14, -NR13R14, -NR13COR14, -NR13CO2R14 and -NR13SO2R14; R4 and R5 are independently hydrogen or C1-6 alkyl;Un compuesto de fórmula (I) **Fórmula**fórmula (I)o una sal farmacéuticamente aceptable de los mismos; en dondem es 0, 1, 2, 3 o 4;1Y e Y2 son independientemente N o CR8 siempre que uno de 1Y e Y2 sea N y el otro sea CR8;X es un grupo enlazante que se selecciona de -CR4 >;= CR5-, -CR4 >;= CR5CR6R7-, -CR6R7CR5 >;= CR4-, -C≡C-, -C≡CCR6R7-, -CR6R7C≡C-, -NR4CR6R7-, -OCR6R7-, -SCR6R7-, -S(O)CR6R7-, -S(O)2CR6R7-, -C(O)NR4CR6R7-, -NR4C(O)CR6R7-, -NR4C(O)NR5CR6R7-, -NR4S(O)2CR6R7-, -S(O)2NR4CR6R7-, -C(O)NR4-, -NR4C(O)-, -NR4C(O)NR5-, -S(O)2NR4- y -NR4S(O)2-;R1 es un grupo que se selecciona de hidrógeno, alquiloC1-6, alq
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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