KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION;고려대학교산학협력단
发明人:
KIM, Won Ki,김원기,CHOI, Yongseok,최용석
申请号：
KRKR2013/004932
公开号：
WO2013/183920A1
申请日:
2013.06.04
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition or a functional health food containing a verbenone derivative and pharmaceutically acceptable salts thereof as active ingredients for treating or preventing a neurodegenerative disease. More specifically, the verbenone derivative according to the present invention reduces nerve cell death and oxidative stress, and is highly effective in preventing ischemic brain damage and inflammatory cell migration in rats, thereby providing the pharmaceutical composition or the functional health food which is useful in treating neurodegenerative diseases.La présente invention concerne une composition pharmaceutique ou un aliment naturel fonctionnel contenant un dérivé de verbénone et des sels pharmaceutiquement acceptables de celui-ci comme principes actifs pour le traitement ou la prévention d'une maladie neurodégénérative. Plus spécifiquement, le dérivé de verbénone selon la présente invention permet de réduire le stress oxydatif et la mort des cellules nerveuses et est très efficace pour empêcher la survenue d'une lésion cérébrale ischémique et la migration des cellules inflammatoires chez les rats, permettant ainsi d'obtenir la composition pharmaceutique ou l'aliment naturel fonctionnel qui est utile dans le traitement de maladies neurodégénératives.본 발명은 베르베논 유도체 및 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 퇴행성 뇌질환 치료용 약학 조성물 또는 건강 기능 식품에 관한 것으로서, 상세하게는 본 발명의 베르베논 유도체는 신경세포사 및 산화적 스트레스를 감소시키고 래트에서의 뇌허혈성 손상 및 염증성 세포의 이주에 대하여 저해능이 탁월하므로 퇴행성 뇌질환 치료에 유용한 약학 조성물 또는 건강 기능 식품을 제공한다.
