The present invention relates to: a composition for controlling stem cell pluripotency, containing an LIN28A methylation inhibitor and a method for screening for an LIN28A methylation inhibitor, and more particularly, to a composition for controlling embryonic stem cell pluripotency or an anticancer composition, which is a composition for controlling stem cell pluripotency or treating cancer, containing an inhibitor for controlling the methylation of the 135th lysine of LIN28A to be methylated by Set7/9, and a method for screening for the inhibitor, wherein the screening method comprises the steps of: (a) making a candidate material come into contact with cells into which the LIN28A gene is introduced (b) measuring the methylation level of the 135th lysine of LIN28A and (c) selecting an inhibitor for controlling the methylation of the 135th lysine of LIN28A. The method of the present invention can effectively screen for a material capable of controlling embryonic stem cell pluripotency or a material having an anticancer activity, and the inhibitor screened for by the method of the present invention controls embryonic stem cell pluripotency, and is thus effective in the preparation of an agent for treating stem cell differentiation disorders or cancer by inhibiting the growth of cancer cells.La présente invention concerne une composition pour réguler la pluripotence de cellules souches, contenant un inhibiteur de la méthylation du LIN28A et un procédé de criblage portant sur un inhibiteur de la méthylation du LIN28A, et plus particulièrement une composition pour réguler la pluripotence de cellules souches embryonnaires ou une composition anticancéreuse, qui est une composition pour réguler la pluripotence de cellules souches ou pour traiter un cancer, contenant un inhibiteur destiné à réguler la méthylation de la 135ème lysine de LIN28A à méthyler par Set7/9, et un procédé pour un criblage portant sur linhibiteur, le procédé de criblage comprenant les étapes de : (a
