The invention provides methods and compositions for treatment of bacterialinfections. The composition may be a combination of factors, which include A0,A1, B1, B2, CO, C1, isoB0, and MAG, in the presence of low level solvent.Methods of the invention include administration of dalbavancin formulationsfor treatment of a bacterial infection, in particular a Gram-positivebacterial infection of skin and soft tissue. Dosing regimens include multipledose administration of dalbavancin, which often remains at therapeutic levelsin the bloodstream for at least one week, providing prolonged therapeuticaction against a bacterial infection. Dosing regimens for renal patients arealso included.
