SANDER, Leif, Erik;MOUNT SINAI SCHOOL OF MEDICINE;BLANDER, Julie, Magarian
发明人:
BLANDER, Julie, Magarian,SANDER, Leif, Erik
申请号：
USUS2012/047087
公开号：
WO2013/012875A3
申请日:
2012.07.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The disclosure features vaccine adjuvants comprising prokaryotic mRNA, and methods of vaccination using the adjuvants. More specifically, the disclosure provides a vaccine composition comprising a nonviable immunogen (e.g., heat-killed bacterium), a tumor antigen, or an immunogenic peptide of microbial or mammalian origin, and an adjuvant, wherein adjuvant comprises prokaryotic mRNA (e.g., bacterial mRNA), as well as the methods of using the vaccine compositions. Further disclosed are the structual features of the prokaryotic mRNA used as the adjuvants.La présente invention concerne des adjuvants vaccinaux qui comprennent de l'ARNm procaryote, et des procédés de vaccination utilisant les adjuvants.
