Systems and methods for low level central plant optimization are provided. A controller for the central plant uses binary optimization to determine one or more feasible on/off configurations for equipment of the central plant that satisfy operating constraints and meet a thermal energy load setpoint. The controller determines optimum operating setpoints for each feasible on/off configuration and generates operating parameters including at least one of the feasible on/off configurations and the optimum operating setpoints. The operating parameters optimize an amount of energy consumed by the central plant equipment. The controller outputs the generated operating parameters via a communications interface for use in controlling the central plant equipment.
