Gamache, Daniel A.,Senchyna, Diane Michelle,Miller, Steven T.,Chatterton, Jon E.,Yanni, John M.
申请号：
AU2012201409
公开号：
AU2012201409B2
申请日:
2012.03.08
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2012201409B220140612.pdf#####RNA interference is provided for inhibition of tumor necrosis factor a (TNFa) by silencing TNFa cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFa converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFa targets, in particular, is useful for treating patients having a TNFa-related condition or at risk of developing a TNFa-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
