#$%^&*AU2017204484A120170727.pdf#####N X R2I The present invention provides non-peptide compounds of formula (1) wherein: X is -(C1-Cs)alkyl-, aryl or -aryl(Cl-Cs)alkyl-； Y is -(Cl-Cs)alkyl- or absent； W is heteroaryl, (C3-C7)carbocycle or aryl, wherein any heteroaryl, (C3-C7)carbocycle or aryl of W is optionally substituted with one or more (e.g. 1, 2, 3, 4 or 5) Z groups； R1 is (Cl-C 8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl or aryl, wherein aryl is optionally substituted with one or more (e.g. 1, 2, 3, 4 or 5) groups selected from (Cl-Cs)alkyl, (C2-Cs)alkenyl, (C2-Cs)alkynyl, (C3C7)carbocycle, halo(Cl-C 3)alkyl, -CN, -NO 2, halogen, -ORa, -SRa, -S(O) 2 NRbRe, -NRbRe, -NRaCORd, -C(O)Ra, -C(O)ORa, and -C(O)NRbRc； R2 is (Cl-Cs)alkyl, (C2-Cs)alkenyl, (C2-Cs)alkynyl or aryl, wherein aryl is optionally substituted with one or more (e.g. 1, 2, 3, 4 or 5) groups selected from (Cl-C 8)alkyl, (C2Cs)alkenyl, (C2-Cs)alkynyl, (C3-C7)carbocycle, halo(Cl-C 3)alkyl, -CN, -NO 2, halogen, -ORe, -SRe, -S(O) 2 NRRg, -NRfRg, -NReCORh, -C(O)Re, -C(O)ORe and -C(O)NRRg； that mimic the streptococcal SspB Adherence Region (BAR) and function as inhibitors of P. gingivalis adherence to streptococci. The invention also provides methods of making and using the inhibitors
