Fred Hutchinson Cancer Research Center;Technische Universität München
发明人:
LIU, Lingfeng,RIDDELL, Stanley R.,BUSCH, Dirk,FRÄßLE, Simon
申请号：
AU2018327225
公开号：
AU2018327225A1
申请日:
2018.09.06
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present disclosure provides tag-specific fusion proteins for selectively detecting molecules containing a strep-tag peptide or cells containing a strep-tag peptide. Disclosed embodiments include tag-specific fusion proteins that can be used in reagents and methods for monitoring and/or modulating immunotherapy cells that express a strep-tag peptide. Embodiments including fusion proteins that specifically bind tagged targets and recombinant host cells comprising polynucleotides encoding the tag-specific fusion proteins are also provided. Immunotherapy cells that express a tagged marker are also provided.
